A Comparative Study of Topical 3% Tranexamic Acid and 35% Glycolic Acid in Melasma and Review of Literature

Aim: To compare the efficacy and safety of topical 3% tranexamic acid gel vs 35% glycolic peel in treatment melasma over face.
 Materials Methods: This is an open labelled, Randomised Controlled Trial(RCT) conducted on 60 patients. Patients were randomly divided equally into 2 groups – Group A B. used twice a day B patients treated with contact period 5 minutes once every weeks. assessed month for 3 months recurrence was next consecutive following treatment. asked to use broad spectrum sunscreen before sun exposure during entire study. Assessment reduction pigmentation made by MASI score, subjective objective valuation (blind observer) photographic comparison. Safety profile side effects.
 Results: The mean value Melasma Area Severity Index(MASI) score group at baseline 14.41 which reduced 7.05 end 3rd month. In group, 14.58 5.96 percentage improvement 52% whereas it 61%. effects minimal this Side more than group. total 8 had follow up. only recurrence. 16.7 % 10.7%.
 Conclusion: Tranexamic novel emerging therapy melasma. study has been found that efficacious as